Commissioning-based analysis of heating, ventilation, and air conditioning systems in biopharmaceutical cleanrooms: enhancing energy efficiency and reducing cost
DOI:
https://doi.org/10.5327/Z2176-94782036Palavras-chave:
benefício econômico; controle de recirculação de ar; desperdício nos ventiladores.Resumo
A redução de custos por meio da melhoria na eficiência energética é um fator determinante para a otimização dos processos operacionais e a sustentabilidade econômica de organizações. Uma forma de se alcançar níveis significativos de eficiência energética é utilizando sistemas de aquecimento, ventilação e ar condicionado, energeticamente eficientes, para novas instalações industriais. As salas limpas, utilizadas em empresas biofarmacêuticas, exigem altas taxas de troca de ar para manter a higienização, o que consome muita energia elétrica. Esse artigo analisou dados coletados de fontes terceirizadas, demonstrando um método usado em uma instalação biofarmacêutica na Irlanda. O objetivo do estudo foi calcular os parâmetros relativos à eficiência energética antes e depois da implementação do controle do volume de ar fresco, visando verificar a eficácia desta abordagem na otimização do consumo de energia e do desempenho da ventilação. O estudo de caso analisou 185 salas limpas de diferentes tamanhos e classificações, observou-se que todas as salas excederam a troca de ar por hora recomendada. Os dados indicaram que salas com volumes mais elevados apresentavam maior desperdício de energia, destacando a importância de otimizar a gestão do fluxo de ar em grandes ambientes de salas limpas. A implementação de controle de volume de ar apresentou uma redução de 8,87% no consumo de energia dos ventiladores, equivalente a uma diminuição de 46.666 unidades de troca de ar por hora, anualmente. Essa diminuição das unidades foi acompanhada por uma redução substancial de desperdício nos ventiladores, totalizando 203.399,1 kWh, economizando mais de €49.055,81 por ano usando estratégias de controle de gradiente de pressão no sistema de ventilação. Em geral, o presente trabalho fornece uma estratégia para melhoria de eficiência energética em indústria biofarmacêutica e destaca os benefícios econômicos e a economia de energia associados à implementação do método proposto. Dessa forma, oferece uma solução prática para reduzir custos operacionais e impacto ambiental, enquanto mantém os padrões de limpeza rigorosos, essenciais para operações em salas limpas.Downloads
Referências
Bahrens, D.; Schaefer, J.; Keck, C.; Runkel, F., 2022. Effects of different air change rates on cleanroom ‘in operation’ status. Drug Development and Industrial Pharmacy, v. 47 (10). 1643-1655. https://doi.org/10.1080/03639045.2022.2043352.
Bhatia, A., 2020. HVAC Design for Pharmaceutical Facilities (GMP’s) (Accessed May 15, 2023) at:. https://pdhonline.com/courses/m333/m333content.pdf
Bhattacharya, A.; Tak, M.; Shoai-Naini, S.; Betz, F.; Mousavi, E., 2022. A systematic literature review of cleanroom ventilation and air distribution systems. Aerosol and Air Quality Research, v. 23, 7. https://doi.org/10.4209/aaqr.220407.
Boyd, G.A., 2011. Development of a performance-based industrial energy efficiency indicator for pharmaceutical manufacturing plants. Duke University, Durham, NC, USA.
Centers for Disease Control and Prevention (CDC), 2003 Appendix B. Air Guidelines for Environmental Infection Control in Health-Care Facilities (2003) (Accessed May 15, 2023) at:. https://www.cdc.gov/infection-control/hcp/environmental-control/appendix-b-air.html
Cetin, Y.; Avci, M.; Aydin, O., 2019. Effect of air exchange rate on particle decay in a cleanroom: a numerical study. E3S Web of Conferences, v. 111, 01037. https://doi.org/10.1051/e3sconf/201911101037.
Cheng, X.; Li, C.; Ma, X.; Huang, C.; Yang, Z.; Shao, X.; Zhang, C.; Xhang, Q., 2023 Pressure gradient control in bidirectional switching between standby mode and production mode in biopharmaceutical cleanroom. Journal of Building Engineering, v. 65, 105816. https://doi.org/10.1016/j.jobe.2022.105816.
Cheng, X.; Li, C.; Ma, X.; Shao, X., 2022. Differential pressure control method for pharmaceutical cleanrooms under variable air supply conditions. Building and Environmental, v. 213, 108849. https://doi.org/10.1016/j.buildenv.2022.108849.
European Federation of Pharmaceutical Industries and Associations (EFPIA), 2022. The Pharmaceutical Industry Figures (Accessed May 15, 2023) at:. https://www.efpia.eu/media/637143/the-pharmaceutical-industry-in-figures-2022.pdf
Fernandez, A, 2019. Smart Cleanroom: the innovative solution to reduce HVAC energy consumption in classified areas. A new HVAC control system intensifi es effi ciency in aseptic pharmaceutical cleanrooms (Accessed May 15, 2023) at:. https://ppsnordic.com/wp-content/uploads/2019/12/Telstar_White_Paper_Smart_Cleanroom.pdf
Hafez, F.S.; Sa'di, B.; Safa-Gamal, M.; Taufiq-Yap, Y.H.; Alrifaey, M.; Seyedmahmoudian, M.; Stojcevski, A.; Horan, B.; Mekhilef, S., 2023. Energy Efficiency in Sustainable buildings: a systematic review of taxonomy, challenges, motivations, methodological, aspects, recommendations, and pathways for future research. Energy Strategy Reviews, v. 45, 101013. https://doi.org/10.1016/j.esr.2022.101013.
Holbrook, D., 2009. Controlling contamination: the origins of clean room technology. History and Technology, v. 25 (3), 173-191. https://doi.org/10.1080/07341510903083203.
Hu, S.-C.; Shiue, A., 2016. Validation and application of the personnel factor for the garment used in cleanrooms. Data in Brief, v. 6, 750-757. https://doi.org/10.1016/j.dib.2015.12.031.
International Energy Agency (IEA), 2018. Market report series: energy efficiency 2018. Paris: IEA (Accessed April 30, 2023) at:. www.iea.org/efficiency2018/.
International Organization for Standardization (ISO), 2015. ISO 14644-1:2015. Cleanrooms and associated controlled environments. Part 1: Classification of air cleanliness by particle concentration. (Accessed April 30, 2023) at:. https://www.iso.org/standard/53394.html
Jozala, A.; Geraldes, D.; Tundisi, L., 2016 Biopharmaceuticals from microorganisms: from production to purification. Brazilian Journal of Microbiology, v. 47, Supplement 1, 51-63. https://doi.org/10.1016/j.bjm.2016.10.007.
Li, C.; Ma, X.; Huang, C-E, 2021. Pressure gradient control strategies based on disturbance rejection for typical pharmaceutical cleanrooms. World Journal of Engineering and Technology, v. 9 (3), 555-564. https://doi.org/10.4236/wjet.2021.93038.
Ljungqvist, B.; Reinmüller, B., 2020. People as a contamination source in pharmaceutical cleanrooms –source strengths and calculated concentrations of airborne contaminants. PDA Journal of Pharmaceutical Science and Technology, v. 75 (2), 119-127. https://doi.org/10.5731/pdajpst.2020.012054.
Loomans, M.; Molenaar, P.; Kort, H.; Joosten, P., 2019. Energy demand reduction in pharmaceutical cleanrooms through optimization of ventilation. Energy and Buildings, v. 202 109346. https://doi.org/10.1016/j.enbuild.2019.109346.
Lyu, W.; Wang, Z.; Li, X.; Yu, Z.; Yang, Y.; Li, J.; Wang, Z.; Sun, X.; Sun, G.; Han, L.; Jing, Y., 2023. Energy-efficient fresh air system with pressure-independent dampers for nearly zero energy buildings. Applied Thermal Engineering, v. 234, 121240. https://doi.org/10.1016/j.applthermaleng.2023.121240
Noussan, M.; Carioni, G.; Degiorgis, L.; Jarre, M.; Tronville, P., 2017. Operational performance of an Air Handling Unit: insights from a data analysis. Energy Procedia, v. 143, 386-393. https://doi.org/10.1016/j.egypro.2017.09.579.
Paramati, S.; Shahzad, U.; Dogan, B., 2022. The role of environmental technology for energy demand and energy efficiency: evidence from OECD countries. Renewable and Sustainable Energy Reviews, v. 153, 111735. https://doi.org/10.1016/j.rser.2021.111735
Permana, I.; Wang, F., 2024. Performance improvement of a biotechnology vaccine cleanroom for contamination control. Journal of Building Engineering, v. 82, 108248. https://doi.org/10.1016/j.jobe.2023.108248.
Simpeh, E.K.; Pillay, J.-P.G.; Ndihokubwayo, R.; Nalumu, D.J., 2022. Improving energy efficiency of HVAC systems in buildings: a review of best practices, International Journal of Building Pathology and Adaptation, v. 40 (2), 165-182. https://doi.org/10.1108/IJBPA-02-2021-0019
Sustainable Energy Authority of Ireland (SEAI), 2022. Prices (Accessed May 28, 2023) at:. https://www.seai.ie/data-and-insights/seai-statistics/prices/
Tan, H.; Wong, K.; Nyakuma, B.; Kamar, H.; Chong, W.; Wong, S.; Kang, H., 2022. Systematic study on the relationship between particulate matter and microbial counts in hospital operating rooms. Environmental Science and Pollution Research, v. 29, 6710-6721. https://doi.org/10.1007/s11356-021-16171-9.
Thatiparti, D.S.; Ghia, U.; Mead, K.R., 2016. Computational fluid dynamics study on the influence of an alternate ventilation configuration on the possible flow path of infectious cough aerosols in a mock airborne infection isolation room. Science and Technology for the Built Environment, v. 23 (2), 355-366. https://doi.org/10.1080/23744731.2016.1222212.
Wang, H.; Liang, C.; Wang, G.; Li, X, 2024. Energy-saving potential of fresh air management using camera-based indoor occupancy positioning system in public open space. Applied Energy, v. 356, 122358. https://doi.org/10.1016/j.apenergy.2023.122358.
Wang, Y.; Li, Y.; Zhou, L., 2015. Pressure gradient control and energy-saving operation strategy study on a multi-zone cleanroom. Procedia Engineering, v. 121, 1998-2005. https://doi.org/10.1016/j.proeng.2015.09.198.
Xu, T., 2002. Airflow design for cleanrooms and its economic implications. Proceedings of the 5th China International Academic Forum & Products Exposition on Contamination Control Technology; November 27-29; Beijing, China (Accessed May 30, 2023) at:. https://www.osti.gov/servlets/purl/832942
Zhang, F.; Shiue, A.; Fan, Y.; Liu, J.; Meng, H.; Zhang, J.; Leggett, G., 2022. Dynamic emission rates of human activity in biological cleanrooms. Building and Environment, v. 226, 109777. https://doi.org/10.1016/j.buildenv.2022.109777.
Zhang, M.; Han, W.; He, Y.; Xiong, J.; Zhang, Y., 2024. Natural ventilation for cooling energy saving: typical case of public building design optimization in Guangzhou, China. Applied Sciences, v. 14 (2), 610. https://doi.org/10.3390/app14020610.
Zhuang, C.; Shan, K.; Wang, S., 2021. Coordinated demand-controlled ventilation strategy for energy-efficient operation in multi-zone cleanroom air-conditioning systems. Building and Environmental, v. 191, 107588. https://doi.org/10.1016/j.buildenv.2021.107588.
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